Topical retinoids influence the rate of cellular turnover and improve skin clarity and photoaged skin. Consequent cutaneous irritation reduces adherence resulting in suboptimal outcomes. A formulation comprised of a double-conjugated molecule containing a retinoid and an alpha hydroxy acid (AHA) has been purposefully developed for individuals with blemish-prone skin.

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Evaluate the effectiveness and tolerability of a double-conjugate retinoid cream (AlphaRet Overnight Cream; AHA-Ret) in improving visible signs of photoaging vs 1.0% retinol or 0.025% tretinoin.

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Evaluate the effects of a new antioxidant containing topical allyl pyrroloquinoline quinone (TAP) on expression of key markers and assess the efficacy and tolerability in subjects with photodamaged skin.

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Skin damage from visible light predominantly results from exposure to the blue light spectrum (400-500 nm) which generates Reactive Oxygen Species (ROS) causing a cascade of harmful effects to skin. Topical antioxidants reduce the effects of free radical damage caused by environmental exposures. This study evaluated a comprehensive topical antioxidant's ability to inhibit ROS production induced by blue light and cigarette smoke (CS) in human skin.

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Investigators sought to evaluate the antioxidant capacity of a comprehensive topical antioxidant (WEL-DS), its ability to protect skin against the oxidizing effects of UVA/UVB radiation, and to assess the effectiveness and tolerability of WEL-DS for visible improvements in facial photodamage.

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Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model.

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Resveratrol is a botanical antioxidant with diverse boilogic effects. This paper reviews the unique antioxidant activity of resveratrol including its anti-aging benefits.

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SkinCeuticals was the first to discover the exact formulation specifications a topical antioxidant must meet in order to penetrate—and protect—the skin. These parameters have become the gold standard for antioxidant formulation.

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Retinoids and alpha- and beta hydroxy acids are common components utilized in regimens for blemish-prone skin. However, balancing efficacy and tolerability is often challenging.​

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Alternatives to hydroquinone (HQ) are desired. We evaluated the efficacy and tolerability of a non-HQ multi-action skin tone corrector (ETCS) developed to inhibit melanin production and improve skin quality. Design and Methods: Twice-daily use of ETCS and ETCS + AHA-Ret, a retinoid-based alpha hydroxy acid cream, was evaluated in subjects with mild to severe dyschromia.

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The periorbital region is susceptible to premature skin aging and among the first areas to manifest age-related changes. Retinoids are highly effective but can be irritating, limiting use in this vulnerable area. A hydrating formulation comprised of a double-conjugated retinoid/alpha hydroxy acid (lactic acid; AHARet-EM) has been developed to address photoaging of the periorbital area. This study evaluated the efficacy, tolerability, and subject satisfaction of nightly application of AHARet-EM, and a regimen that included application of a peptide-rich eye cream (InF-E; AM) and AHARet-EM (PM).

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Barrier properties of the stratum corneum inhibit delivery of topical ingredients containing large molecules to desired targets in the skin. This study evaluated the efficacy and tolerability of a skincare regimen comprised of a hyaluronic acid-based serum (InF-HA) and a peptide-rich cream (InF-PEP) containing large molecular ingredients designed to improve the appearance and overall quality of skin.

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Dr. Watchmaker discusses her own experience using Mystro Active Balance Serum in patients looking to improve erythema and their post-procedure regimen.

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Dr. Watchmaker reviews a multi-center study1 that evaluated the ability of Mystro Active Balance Serum to improve the overall quality of the skin.

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Dr. Watchmaker reviews encouraging results from a clinical study that evaluated the compatibility of Mystro Active Balance Serum for use with patients undergoing non-ablative fractional laser treatments and medium depth chemical peels.

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Dr. Watchmaker discusses patient-report outcomes from a study1 that evaluated Mystro Active Balance Serum, where patients reported decreased pore visibility and skin greasiness as well as high patient satisfaction reported throughout the study.

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Dr. Watchmaker shares statistically significant results from a clinical trial that assessed the ability Mystro Active Balance Serum to improve redness, texture, dullness, pore size, and uneven pigmentation in the skin.

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Dr. Watchmaker reviews the concept of skin homeostasis and discusses new research1 in which she and her colleagues evaluated Mystro Active Balance Serum for the purposes of restoring skin homeostasis.

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Dr. Draelos discusses the process of defining skin quality and the skin parameters that were chosen for this purpose while conducting research on Mystro Active Balance Serum.

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Dr. Draelos discusses a study that focused on plant adaptogens targeting homeostasis (PATH), a proprietary system of adaptogens that, when purposefully combined, supports the skin’s natural ability to adapt and achieve balance.

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There is growing interest in skincare products designed for men. This pilot study evaluated the efficacy and tolerability of a comprehensive antioxidant product in men. This 12-week study evaluated improvements from baseline in erythema, lines/wrinkles, skin tone, texture, brightness, dryness/flaking and pores (6-point scale), global improvements (5-point scale), and sebum levels following daily application in males with mild to moderate photodamaged skin.

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To meet the unique needs of aging skin of the neck, a new neck cream that enhances nitric oxide availability has been developed to visibly improve signs of aging and overall quality of skin.​

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To evaluate skin barrier and hydration effects of a new rebalancing moisture treatment (TRMT) and to assess efficacy and tolerability in subjects with photodamaged skin.

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Topical antioxidants and retinoids are foundational components of an effective skincare regimen.

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